The molecular machinery of autophagy: unanswered questions

The molecular machinery of autophagy: unanswered questions.

Autophagy is a process in which cytosol and organelles are sequestered within double-membrane vesicles that deliver the contents to the lysosome/vacuole for degradation and recycling of the resulting macromolecules. It plays an important role in the cellular response to stress, is involved in various developmental pathways and functions in tumor suppression, resistance to pathogens and extensio...

The regulation of autophagy - unanswered questions.

Autophagy is an intracellular lysosomal (vacuolar) degradation process that is characterized by the formation of double-membrane vesicles, known as autophagosomes, which sequester cytoplasm. As autophagy is involved in cell growth, survival, development and death, the levels of autophagy must be properly regulated, as indicated by the fact that dysregulated autophagy has been linked to many hum...

E-Learning: some unanswered questions

The Structure of Human Neuromuscular Junctions: Some Unanswered Molecular Questions

The commands that control animal movement are transmitted from motor neurons to their target muscle cells at the neuromuscular junctions (NMJs). The NMJs contain many protein species whose role in transmission depends not only on their inherent properties, but also on how they are distributed within the complex structure of the motor nerve terminal and the postsynaptic muscle membrane. These mo...

The Key Questions Remain Unanswered

First, we described an illustrative notional planning magnitude for each threat based on a stylized threat and risk assessment, while noting that a more comprehensive threat and risk assessments could reveal that these illustrative magnitudes were either too high or too low. Our illustrative threat assessments relied on historical data revealing observed frequencies and consequences of each thr...